It is one of the most difficult challenges for industry and engineers to increase heat transfer, which is one of the ultimate aims of increasing efficiency, lowering dimensions, and minimizing temperature variations. Numerous techniques have been developed over the past few years to increase heat transfer. In order to improve the thermal characteristics of the base fluid, nanoparticles can be introduced into the base fluid. An investigation of the experimental results has revealed that nanoparticles added to the base fluid greatly enhance the conduction heat transfer coefficient. Our research explores the forced heat transfer in a microchannel filled with iron oxide nanofluid in water-based fluids with varying volume fractions as well as pure water. It has been investigated how several factors, such as nanofluids with varied volume fractions and slip and non-slip flow, influence the outcome. This investigation was conducted through quantitative analysis. A model has been developed in Fluent software that demonstrates the influence of these factors, and simulations have been performed with varying fractions of nanoparticles and slip and non-slip boundary conditions. Results acquired are generally in agreement with previous numerical and experimental results. In this study, it has been shown that increasing the volume fraction of nano increases the Nusselt number, stimulating heat transfer. The volume fraction of nanoparticles contributes considerably to the increase in the conductivity of the nanofluid. At the entrance to the channel, the Nusselt number increases by 4% by volume within Reynolds number 50. The Nusselt number increases by 0.01 at the entrance to the channel by 60%, and by 30% in the developed area by 30% in comparison with pure water under the same conditions.